Metabolic Fate of 2-Methyl-3-o-tolyl-4 (3H)-quinazolinone. I. 2-Nitrobenzo-o-toluidide as an Urinary Metabolite of 2-Methyl-3-o-tolyl-4 (3H)-quinazolinone in Human
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چکیده
منابع مشابه
Diethyl(μ3-2-methyl-4-oxo-4H-pyran-3-olato-κ4 O 3,O 4:O 3:O 3)tris(μ2-2-methyl-4-oxo-4H-pyran-3-olato-κ3 O 3,O 4:O 3)trizinc toluene disolvate
The title compound, [Zn3(C2H5)2(C6H5O3)4]·2C7H8, crystallizes with one complex mol-ecule solvated by two mol-ecules of toluene in the asymmetric unit. The Zn(II) ions are coordinated by two terminal ethyl (Et) groups and four maltolate ligands, which act as μ3- and μ2-bridges. The metal atoms are arranged in an incomplete cubane Zn3O4 core structure, derived from one EtZnO3 tetra-hedron, one Et...
متن کاملSynthesis and antiviral bioactivities of 2-aryl- or 2-methyl-3-(substituted- benzalamino)-4(3H)-quinazolinone derivatives.
A simple and general method has been developed for the synthesis of various4(3H)-quinazolinone derivatives by the treatment of the appropriate 3-amino-2-aryl-4(3H)-quinazolinone with a substituted benzaldehyde in ethanol. The structures of the compoundswere characterized by elemental analysis, IR, (1)H-NMR and (13)C-NMR spectra. The title 2-aryl- or 2-methyl-3-(substituted-benzalamino)-4(3H)-qu...
متن کامل2-Methyl-3-(2-methylphenyl)-7-nitroquinazolin-4(3H)-one
In the title methaqua-lone analogue, C(16)H(13)N(3)O(3), the 2-tolyl group is almost orthogonal [dihedral angle = 85.20 (5)°] to the fused ring system (r.m.s. deviation of fitted non-H atoms = 0.029 Å). In the crystal, twofold symmetry generates two-mol-ecule aggregates linked by C-H⋯O and π-π inter-actions [ring centroid-centroid distance = 3.4967 (6) Å].
متن کامل2-Methyl-3-p-tolyl-3H-benzo[e]indole-1-carbonitrile
In the title compound, C(21)H(16)N(2), the dihedral angle between the benzoindole and tosyl ring systems is 71.99 (7)°. In the crystal, mol-ecules are linked into centrosymmetric dimers by pairs of C-H⋯N hydrogen bonds, generating R(2) (2)(16) loops.
متن کاملp-Tolyl 2-O-benzoyl-3-O-benzyl-4,6-O-benzylidene-1-thio-α-l-idopyranoside
The title compound, C(34)H(32)O(6)S, is an ido-configured thio-glycoside building block for heparan sulfate fragments. It contains disordered tolyl and O-benzyl groups with occupancy ratios of 0.539 (13):0.461 (13) and 0.613 (13):0.387 (13), respectively, as determined from a weakly diffracting crystal. The fused rings adopt chair conformations with the mol-ecules packing into a three-dimension...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1970
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.18.133